Figure 9.

Impaired CS responses in B cell–deficient μMT mice. CS was induced in relatively hyporeactive C57Bl/6 control mice (groups A and B), and in C57Bl/6-Igh-6 (μMT) B cell–deficient mice (groups C and D) by topical application of PCl on days 0 and 1. Then, 6 d later the mice were skin challenged to elicit CS by painting both ears with 0.8% PCl. The resulting CS ear swelling responses were measured with a dial caliper by comparing thickness before, versus 2 and 24 h after challenge. Net ear swelling was calculated by subtracting ear thickness before challenge from that at 2 and 24 h after challenge. Number of mice in each group was eight. *P <0.01, compared with C57Bl/6 mice controls (group B).