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. 1997 Oct 6;186(7):1077–1085. doi: 10.1084/jem.186.7.1077

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Effect of IL-8 on virus yield in IFN-treated cells. Confluent cells in microtiter plates were pretreated overnight with IL-8 (10 ng/ml) followed by IFN-α at indicated concentrations for 20 h. Viruses were added at doses that were previously determined to cause maximum CPE within 24 h. The following virus/cell systems were used: EMCV/WISH (A), poliovirus/WISH (B), HSV-1/MRC-5 (C), and VSV/normal fibroblasts (D). Infectious virus yield was quantitated in terms of PFU/ml as described in Materials and Methods. IL-8 itself had no effect on the CPE. Data are from an average of three experiments. *Statistical significance at P <0.005 when compared to IFN alone at the indicated concentrations. VC, virus control; VC+IL-8, virus control that was treated with IL-8. All other treatments, as indicated, are in the presence of virus.