Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1997 Oct 6;186(7):1137–1147. doi: 10.1084/jem.186.7.1137

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

LACK DNA vaccination induces a systemic and durable immune response to mice infected with L. major. (A) BALB/c mice (n = 6/ group) were initially immunized with LACK or control DNA (100 μg) and boosted 2 wk later. 5 wk after the boost, mice were challenged in the hind footpad with 10⁵ live L. major metacyclic promastigotes. (B) In a separate experiment, BALB/c mice (n = 6/group) were initially immunized and boosted 2 wk later with LACK or control DNA (100 μg) in the right hind footpad. 2 wk after the boost, mice were challenged with 10⁵ live L. major metacyclic promastigotes in the same or the opposite footpad to which they recieved LACK DNA vaccination.

LACK DNA vaccination induces a systemic and durable immune response to mice infected with L. major. (A) BALB/c mice (n = 6/ group) were initially immunized with LACK or control DNA (100 μg) and boosted 2 wk later. 5 wk after the boost, mice were challenged in the hind footpad with 10⁵ live L. major metacyclic promastigotes. (B) In a separate experiment, BALB/c mice (n = 6/group) were initially immunized and boosted 2 wk later with LACK or control DNA (100 μg) in the right hind footpad. 2 wk after the boost, mice were challenged with 10⁵ live L. major metacyclic promastigotes in the same or the opposite footpad to which they recieved LACK DNA vaccination.