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. 1997 Nov 3;186(9):1407–1418. doi: 10.1084/jem.186.9.1407

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Expression of mediators of cytotoxicity in CD8⁺ T cell subsets. After surface staining of freshly isolated CD8⁺ cells with CD45RA and CD27 mAbs, cells were fixated and permeabilized and intracellularly present perforin and granzyme B were detected with specific mAbs. The histograms show the staining for the intracellular proteins. Dotted lines indicate the negative controls. The positive cell fraction is painted black. The dot-plots show the distribution of positive cells (black) among the total cell population (gray). Note that the different dot-plot staining is due to the use of either biotinylated CD27 mAb in combination with red 670 or FITC-labeled CD27 mAb.