Table 3.
Parasite Burdens in Tissues of ICSBP Mutant Mice during L. major Infection
| Tissues | Days after infection | |||||||
|---|---|---|---|---|---|---|---|---|
| 6 | 19 | 49 | 53 | |||||
| Foot (log2 titer per mg of tissue) | ||||||||
| ICSBP−/− | 10 ± 1 | >15 | 13 ± 1 | 8 ± 4 | ||||
| (n = 3) | (n = 3) | (n = 3) | (n = 3) | |||||
| ICSBP+/+ | 1 | >15 | nd† | 2 ± 2 | ||||
| (n = 2) | (n = 2) | (n = 3) | (n = 2) | |||||
| Spleen (log2 titer per 106 of nucleated cells) | ||||||||
| ICSBP−/− | –* | – | 14 ± 2 | 12 ± 1 | ||||
| (n = 5) | (n = 4) | |||||||
| ICSBP+/+ | – | – | nd | nd | ||||
| (n = 3) | (n = 3) | |||||||
| Draining LN (log2 titer per 106 of nucleated cells) | ||||||||
| ICSBP−/− | – | – | 17 ± 1 | 14 ± 1 | ||||
| (n = 5) | (n = 4) | |||||||
| ICSBP+/+ | – | – | 2 ± 1 | 1 | ||||
| (n = 3) | (n = 3) | |||||||
*
–, not done.
†
nd, not detectable.