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. 1997 Nov 3;186(9):1431–1439. doi: 10.1084/jem.186.9.1431

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Immunohistochemistry of BCG granulomata in SRKO and wild-type (129) mice. Livers were collected from SRKO and wild-type (129) mice at day 25 of BCG infection and frozen in OCT embedding medium. Sections of liver were cut and immunostained with a range of primary antibodies. a, c, e, and g: control sections. b, d, f, and h: SRKO sections. (a and b) F4/80; resident macrophages (Kupffer cells) and newly recruited activated macrophages forming granulomata are stained. (c and d) FA11; macrosialin is found in all macrophages and here shows the similar morphology of granulomas in wild-type and SRKO mice. (e and f) TIB 120; both 129 and SRKO Kupffer cells and granuloma macrophages express high levels of MHC class II. (g and h) 2F8, which recognizes the type I and II SR-A. (g) Shows that SR-A is expressed on Kupffer cells, freshly recruited macrophages, and the hepatic endothelium, whereas h shows the absence of SR-A in the SRKO sections. Original magnification: ×500.