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. 1997 Nov 3;186(9):1431–1439. doi: 10.1084/jem.186.9.1431

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Role of SR-A in a model of endotoxic shock. SRKO and 129 mice were injected intraperitoneally with 10⁷ CFU of BCG. At days 12–14 of infection, the mice were injected with various doses of LPS (μg). The mice were observed for 5 d and mortality was noted. The percentage of survival for each dose point represents the mean mortality of a group of at least five mice. The dose of LPS producing 50% mortality (LD₅₀; ng/ml) of the 129 mice is: 34.1 ± 6.6 (standard error), which is significantly different from the SRKO LD₅₀: 4.7 ± 1.5; P <0.0001.