Table 1.
A Blocking Antibody to TNF-α (TN3 19.12) Provides Partial Protection in a Model of Endotoxic Shock
| Time after LPS challenge | Survival | |||||
|---|---|---|---|---|---|---|
| PBS | TN3 19.12 | |||||
| h | ||||||
| Expt. 1 | 12 | 2/5 | 5/5 | |||
| 36 | 1/5 | 3/5 | ||||
| Expt. 2 | 12 | 3/5 | 5/5 | |||
| 36 | 0/5 | 4/5 | ||||
SRKO mice were injected intraperitoneally with 107 CFU of BCG. At day 14 of infection, groups of five mice were given either 250 μg of TN3 19.12 in 200 μl of PBS, or 200 μl of PBS alone. 10 h later mice were challenged with 25 μg of LPS. Results represent mortality at 12 h and 36 h after LPS challenge. Results from two independent experiments are shown.