Figure 3.

CCR2-deficient mice cannot clear Listeria infection. Wild-type (open bars) and ccr2 ^−/− (black bars) mice were injected intravenously with 2,500 CFU of L. monocytogenes. Listerial titers in liver, spleen, and lung were determined from mice killed 5 d after infection or at autopsy for mice that died after 4 d. Values represent mean ± SEM of 15 wild-type or ccr2 ^−/− mice. For all organs, the difference between wild-type and mutant mice is significant (P <0.0002 by Mann-Whitney two sample nonparametric analysis).