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. 1997 Dec 1;186(11):1873–1884. doi: 10.1084/jem.186.11.1873

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Schematic representation of SBF, SBT, SBB, and SBM constructs. The SBM construct consists of the murine c-myc gene exon 2, 3, and 3′ flanking sequences (35). All share common regulatory elements, SV40 enhancer (dark oval) and β-globin promoter (stippled) cojoined as in SBM. For SBF, these regulatory elements are linked to the mouse genomic c-fos sequences (hatched box, exons 1-4; solid bar, introns 2-3 and flanking sequences). The CIIIa sea urchin marker (dark box) was inserted into the 3′ end, where unstable sequences have been identified. For SBT, the same regulatory elements are linked to the human TGF-α cDNA (hatched box) bound to the human growth hormone (hGH) 3′ untranslated region of the last exon (open box), the polyadenylation signal and the 3′ flanking region (hGH) (solid bar). For the SBB, the same regulatory elements are linked to the human bcl-2 cDNA (hatched box) bound to the hGH last 5 exons (open boxes, exons; solid bar, introns), polyadenylation signal and 3′ flanking sequences (hGH) (solid bar).