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. 1997 Dec 1;186(11):1873–1884. doi: 10.1084/jem.186.11.1873

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bcl-2–independent c-myc–dependent apoptosis in transgenic mice. (a) RT-PCR analysis of renal bcl-2 (280 bp fragment) and bax (311-bp fragment) expression in SBM 9 and 75, control littermates and progenies of SBM/p53^−/− matings. Comparable levels of bcl-2 (top) and bax (bottom) are seen in all the lines studied. Similar levels are also seen for the S16 internal control. c, control reaction with water replacing cDNA, M, molecular weight marker. (b) RT-PCR expression analysis for the SBB transgene (280-bp fragment) for four different SBB lines (10, 11, 17, and 20) is shown in kidney (K) and other organs (Lu, lung; S, spleen; B, brain; Li, liver; C, control). A (C57BL/6J × CBA/J)F1 non-transgenic kidney control is also included. S16, internal control (103 nt).

bcl-2–independent c-myc–dependent apoptosis in transgenic mice. (a) RT-PCR analysis of renal bcl-2 (280 bp fragment) and bax (311-bp fragment) expression in SBM 9 and 75, control littermates and progenies of SBM/p53^−/− matings. Comparable levels of bcl-2 (top) and bax (bottom) are seen in all the lines studied. Similar levels are also seen for the S16 internal control. c, control reaction with water replacing cDNA, M, molecular weight marker. (b) RT-PCR expression analysis for the SBB transgene (280-bp fragment) for four different SBB lines (10, 11, 17, and 20) is shown in kidney (K) and other organs (Lu, lung; S, spleen; B, brain; Li, liver; C, control). A (C57BL/6J × CBA/J)F1 non-transgenic kidney control is also included. S16, internal control (103 nt).