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. 1997 Dec 1;186(11):1831–1841. doi: 10.1084/jem.186.11.1831

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Basic FGF blocks LPS-induced endothelial apoptosis and animal death. (A) C₅₇BL/ 6 mice injected intravenously with 800 ng bFGF 30 min before, and 5 min, 1 and 2 h after, an intraperitoneal injection of 175 μg of LPS/25g mouse. Endothelial apoptosis was assessed as in Fig. 1 by TUNEL assay. (B) Actuarial (Kaplan-Meier) survival curves of C₅₇BL/6 treated as in A. The number in parenthesis indicates the number of animals in each group.

Basic FGF blocks LPS-induced endothelial apoptosis and animal death. (A) C₅₇BL/ 6 mice injected intravenously with 800 ng bFGF 30 min before, and 5 min, 1 and 2 h after, an intraperitoneal injection of 175 μg of LPS/25g mouse. Endothelial apoptosis was assessed as in Fig. 1 by TUNEL assay. (B) Actuarial (Kaplan-Meier) survival curves of C₅₇BL/6 treated as in A. The number in parenthesis indicates the number of animals in each group.