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. 1997 Dec 1;186(11):1911–1922. doi: 10.1084/jem.186.11.1911

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Distinct signaling mechanisms of DP thymocyte apoptosis as revealed by differential sensitivity to bcl-2. DP thymocytes isolated from wild-type (B6) and bcl-2 transgenic (bcl-2 TG) mice were cultured with three distinct apoptotic stimuli: dexamethasone (10⁻⁶ M), platebound anti-fas antibodies, and platebound anti-TCR and anti-CD28. It can be seen that transgenic bcl-2 expression abrograted TCR-CD28–mediated apoptosis but not fas-mediated apoptosis of DP thymocytes. It might be noted that thymocyte death by TCR-CD28 engagement does not involve glucocorticoids as the steroid inhibitor RU486 only blocked death induced by dexamethasone but not by TCR-CD28 (data not shown).