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. 1997 Dec 1;186(11):1923–1931. doi: 10.1084/jem.186.11.1923

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Humoral immune responses of sHEL/Ig^HEL (A) and Ig^HEL(B) mice that overexpress CD19 in response to immunization with HEL. 2-mo-old mice were injected i.p. with HEL or PBS mixed with CFA on days 0 and 21 (arrows), and were bled at the indicated times. Levels of serum anti-HEL IgM^a antibodies for individual mice (dots or squares) were determined by ELISA. Mean antibody levels are shown as solid (hCD19^+/+) or dashed (hCD19^–/–) lines. The dashed horizontal lines (arrowhead) delimit the 95% confidence interval for the log normal distribution of anti-HEL antibody levels observed in unimmunized sHEL/Ig^HEL mice.