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. 1997 Dec 15;186(12):2013–2021. doi: 10.1084/jem.186.12.2013

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Life span of Syk ^−/− immature B cells is increased by expression of Bcl-2. Chimeric mice reconstituted with Syk ^−/−/3-83 fetal livers with and without Bcl-2Tg were given a 12-h pulse of BrdU. Graph shows the percentage of splenic 3-83⁺ B cells that were also labeled with BrdU either 4 or 8 d after the BrdU pulse. At each time point, spleens from three or four mice were analyzed by quantitative immunohistology as previously described (4). The lines are drawn between median values. The number of cells enumerated was 168–263 cells/spleen in the Syk ^−/−/ 3-83 chimeras and 673–994 cells/spleen in the Syk ^−/−/3-83/Bcl-2Tg chimeras.