Table 2.
Incidence of Diabetes after Cotransfer of OT-I and OT-II Cells
| No. cells transferred | No. mice diabetic/ total No. mice (%) | |||||
|---|---|---|---|---|---|---|
| OT-I | OT-II | |||||
| 5 × 106 | − | 18/18 | (100%) | |||
| 0.25 × 106 | − | 0/26 | (0%) | |||
| 0.25 × 106 | 2 × 106 | 15/22 | (68%) | |||
| − | 2 × 106 | 0/12 | (0%) | |||
| − | 10 × 106 | 0/3 | (0%) | |||
0.25 × 106 OT-I cells were transferred either alone or together with 2 × 106 OT-II cells into sex matched RIP-mOVA mice of 6–8 wk of age. Coinjected recipients developed diabetes between day 6 and 10 after adoptive transfer and were sacrificed for histological verification of diabetes after a further 5–10 d. Mice which did not become diabetic were followed for 60–210 d. Shown are the results collected from 5 coinjection experiments with groups of 3–5 mice. The first two rows of this table were included from Table 1 for comparison.