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. Author manuscript; available in PMC: 2008 Jan 15.
Published in final edited form as: Neuroscience. 2007 Oct 5;150(4):796–806. doi: 10.1016/j.neuroscience.2007.10.002

Fig. 1.

Fig. 1

Cardiovascular effects of MCH. Dose-response for decreases in mean arterial pressure (MAP; A) and heart rate (HR; B) responses to microinjections (100 nl) of MCH (0, 0.25, 0.5, 0.75, and 1 mM) into the mNTS (n = 28); 0 mM refers to normal saline (pH 7.4) which elicited no responses (indicated by # symbol). The decreases in MAP and HR elicited by 0.5 mM concentration of MCH were significantly greater than those of other concentrations (*P < 0.001–0.01). Comparison of MAP (C) and HR (D) responses induced by microinjections to L-Glu (5 mM) and MCH (0.5 mM) into the mNTS of urethane-anesthetized (n = 9; dark bars) and unanesthetized decerebrate (n = 8; open bars) rats; L-Glu or MCH-induced decreases in MAP and HR were not statistically different (P > 0.05) in the two groups of rats. Effect of vagotomy on MCH-induced effects on MAP (E) and HR (F) (n = 7); ipsilateral (ipsilat) and bilateral (bilat) vagotomy did not significantly (P > 0.05) alter MCH-induced depressor responses but the HR responses were significantly (*P < 0.05) attenuated.