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. 2001 Mar 19;152(6):1279–1288. doi: 10.1083/jcb.152.6.1279

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Primary and secondary structure of Xenopus U2 snRNA. Internal modified nucleotides are highlighted by circles (pseudouridines) and squares (2′-O-methylated residues). The Sm binding site is indicated by a hatched gray box. Sequences known or predicted to be involved in intermolecular interactions are indicated: the thick line denotes bases interacting with the branch site of pre-mRNA; sequences boxed in dark gray, medium gray, and light gray are involved in U2-U6 interactions called Helix I, Helix II, and Helix III, respectively (Nilsen 1998). The arrows indicate mutations introduced into the Sm binding site (Sm-Mut).