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. 2002 Jan 21;156(2):337–348. doi: 10.1083/jcb.200110003

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Copyright © 2002, The Rockefeller University Press

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Figure 2. — Characterization of βIV-spectrin and its gene products. (A) Schematic diagram of the βIVΣ1- and Σ6-spectrin isoforms. The gene trap vector was inserted between exons encoding the spectrin repeat 12 of the βIV-spectrin gene. (B) Sequence of the 5′ region of βIVΣ6-spectrin cDNA and its comparison with the corresponding region of βIVΣ1-spectrin cDNA. The sequence of Σ6 diverges upstream of the nucleotide 4079 of Σ1 (arrow). (C) Northern blot analysis of βIV-spectrin expression in brains from wild-type (+/+), heterozygous (+/−), and homozygous (−/−) mutant mice. The regions of the 5′- and 3′-probes are indicated in (A). Positions of the 28S and 18S rRNAs are indicated. (D) Western blot analysis of βIV-spectrin in brain lysates from wild-type (+/+), heterozygous (+/−), and homozygous (−/−) mutant mice. Positions of size markers are indicated in kD on the left. The sequence data are available from Genbank/EMBL/DDBJ accession no. AB055618 for βIVΣ1-spectrin and AB055619, AB055620, AB055621 for βIVΣ6-spectrin.