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. 2002 Jan 21;156(2):337–348. doi: 10.1083/jcb.200110003

Figure 6.

Figure 6.

Clustering of VGSC at AIS of βIV-spectrin –null cerebral, hippocampal, and cerebellar neurons. Cerebral cortex (A, A′, B, and B′), hippocampus (C, C′, D, and D′), and cerebellum (E, E′, F, and F′) of wild-type (A, A′, C, C′, E, and E′) and βIV-spectrin–null (B, B′, D, D′, F, and F′) mice were stained with anti–βIV-spectrin (A, B, C, D, E, and F) together with anti–pan-sodium channel (pan-SC; A′, B′, C′, and D′) or anti-Nav1.6 (E′ and F′). Arrowheads indicate AIS of cerebral (A, A′, and B′), hippocampal pyramidal (C and C′), and Purkinje (E and E') neurons. The granular layer (G), Purkinje cell layer (P), and molecular layer (M) of the cerebellum are separated by dotted lines (E, E′, F, and F′). Mice were killed at 3 mo of age. Bars, 20 μm.