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. 2002 Apr 15;157(2):303–314. doi: 10.1083/jcb.200201089

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Copyright © 2002, The Rockefeller University Press

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Figure 3. — Low bone mass in Lrp5 ⁻ ^/ ⁻ mice. (A) Radiograph of the whole body of 2 mo-old wild-type and Lrp5 ⁻ ^/ ⁻ mice showing decreased lucency of the entire Lrp5 ⁻ ^/ ⁻ skeleton. (B) Histological analysis of vertebrae from 2-mo-old wild-type and Lrp5 ⁻ ^/ ⁻ mice showing low bone mass in the mutant mice. (C) Histological analysis of vertebrae from 2-wk-old wild-type and Lrp5 ⁻ ^/ ⁻ mice showing a decreased number of trabeculae in the primary spongiosa of Lrp5 ⁻ ^/ ⁻ mice. (D) Lrp5 ⁻ ^/ ⁻ mice have a lower bone mass throughout life. Green triangle indicates a significantly lower bone mass in Lrp5 ^+/− mice. Asterisks indicate a statistically significant difference between two groups of mice (P < 0.05). Error bars represent SD.