Table 1.
Frequencies of the polymorphisms located in ASMT promoter B in ASD patients and controls
| ASD (n= 278) | Controls (n= 255) | |
|---|---|---|
| SNPs | ||
| rs4446909 | ||
| f(G) | 0.77 | 0.70 |
| P value (Pc valuea) | 0.006 (0.10) | |
| OR [95% CI]b | 1.5 [1.1–2] | |
| rs5989681 | ||
| f(G) | 0.73 | 0.65 |
| P value (Pc value) | 0.007 (0.12) | |
| OR [95% CI] | 1.4 [1.1–2] | |
| P1BC | ||
| f(G) | 0.90 | 0.90 |
| P value | 0.78 | |
| rs6644635 | ||
| f(C) | 0.65 | 0.63 |
| P value | 0.66 | |
| Haplotypes3 | ||
| H1 GGGC | 0.36 | 0.27 |
| P value (Pc value) | 0.002 (0.04) | |
| H2 GGGT | 0.26 | 0.28 |
| P value | 0.54 | |
| H3 ACGC | 0.21 | 0.29 |
| P value (Pc value) | 0.005 (0.08) | |
| H4 GGAT | 0.097 | 0.09 |
| P value | 0.78 | |
| H5 GCGC | 0.055 | 0.057 |
| P value | 0.88 | |
Abbreviations: ASD, autism spectrum disorders; CI, confidence interval; OR, odds ratio; SNP, single nucleotide polymorphism.
a
Pc value: Significance levels corrected for multiple comparisons using a step-down permutation procedure (comprising 100,000 permutations).
b
Odds ratio: major allele vs minor allele.
c
Haplotype using rs4446909, rs5989681, P1BC and rs6644635.
Results with significance < 0.05 are indicated in bold.