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. 2001 Dec 24;155(7):1173–1184. doi: 10.1083/jcb.200108119

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Copyright © 2001, The Rockefeller University Press

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Figure 5. — BIK1 is essential for viability of polyploids. (A) A series of bik1Δ strains of the indicated ploidy was transformed with a 2μ BIK1 URA3 plasmid and plated on medium containing 5-fluoroorotic acid (5-FOA). 5-fluoroorotic acid selects for the loss of the BIK1 URA3 plasmid revealing the growth defect of triploid and tetraploid bik1Δ strains at 24°C. Control BIK1 strains of the same ploidy do not have a detectable growth defect (Galitski et al., 1999; unpublished data). (B) Growth of BIK1- and bik1-CTΔ40–containing triploids. Serial fivefold dilutions from cultures of the indicated strains at a density of 5 × 10⁷ cells/ml were plated. The indicated strains were spotted onto YPD medium.