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. 2003 May 26;161(4):805–816. doi: 10.1083/jcb.200212116

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Copyright © 2003, The Rockefeller University Press

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Figure 4. — Developmental switch in neuronal expression of TARPs. Immunoblotting shows that γ-4 protein levels peak in rat pups at postnatal day 6 (P6) and decline thereafter in cerebral cortex. In contrast, expression of stargazin (STG), γ-3, and γ-8 appear later and progressively increase during animal maturation. In situ hybridization at embryonic day 16 (E16) shows that γ-4 mRNA but not that of other TARPs occurs at extremely high levels throughout the nervous system in cortical plate (CP), olfactory epithelium (OE), dorsal root ganglia (DRG), and spinal cord (SC). Some γ-4 mRNA also occurs in peripheral tissues such as the intestine (IN).