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. 2003 May 26;161(4):727–736. doi: 10.1083/jcb.200210156

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Copyright © 2003, The Rockefeller University Press

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Figure 7. — Model for stabilization of synaptic gene expression through stabilization of musk expression by agrin from motor nerve terminal. Agrin secreted from nerve terminal activates preexisting MuSK to induce expression of musk via its N-box (i) by organizing an NRG/ErbB pathway, involving MuSK-induced recruitment of ErbB receptors and of muscle-derived NRG and (ii) by MuSK-induced activation of JNK (via Rac/Cdc42). With musk expression stabilized, the same pathways are used for AChR and erbB expression. Expression may be strengthened by NRG-1 secreted from nerve terminal. Complete inhibition of Agrin-induced musk transcription in C2C12 cells by overexpression of inactive ErbBs (HER2KM and HER4KM) and by dominant-negative JNK suggests that the two pathways are connected. The model is based on present data (solid arrows) and references cited (broken arrows).