Table 2.
Concentration-related effects of cinnamophilin on the conduction system of guinea-pig isolated heart
|
Cinnamophilin (μM) |
||||||
|---|---|---|---|---|---|---|
| Control | 1 | 3 | 10 | 30 | Washout | |
| BCL | 309±8 | 315 ± 8 | 316 ± 8 | 317±8 | 321±7 | 310±6 |
| SA | 12±1 | 12±1 | 13±1 | 13±1 | 14±2 | 13±1 |
| AH | 56±2 | 58±2 | 59±2 | 62±3 | 72±3* | 66±3 |
| HV | 16±1 | 15±1 | 16±1 | 17±2 | 17±1 | 16±1 |
| VRT | 181±4 | 176±4 | 170±6 | 168±6 | 159±8* | 169±5 |
| WCL | 183±4 | 193±5 | 204±5* | 214±6** | 234±7*** | 203±6 |
| AERP | 62±3 | 67±4 | 68±4 | 72±3 | 77±4 | 69±6 |
| AVNERP | 143±4 | 159±6 | 171±7* | 186±7*** | 215±8*** | 179±8* |
| HPFRP | 227±5 | 229±5 | 242±6 | 247±6 | 256±7* | 246±8 |
| VERP | 154±5 | 152±6 | 153±7 | 166±5 | 182±7* | 150±6 |
Abbreviations: AH, atrio-His bundle conduction interval; AERP, atrial effective refractory period; AVNERP, AV nodal effective refractory period; BCL, basic cycle length; HPFRP, His-Purkinje system functional refractory period; HV, His-ventricular conduction interval; SA, sinoatrial conduction interval; VERP, ventricular effective refractory period; VRT, ventricular repolarization time (VT interval); WCL, Wenckebach cycle length.
Data (in ms) were obtained from 14 experiments and are expressed as means±s.e.mean.
*P<0.05, **P<0.01 and ***P<0.001 compared to respective control value by ANOVA, followed by Dunnett's t-test for multiple comparisons.