Table 3.
Effects of cinnamophilin, diltiazem, SQ29548 with ozagrel, glibenclamide and SOD with catalase, on reperfusion-induced VF in guinea-pig isolated hearts
| Groups | n | Incidence of VF | Duration of VF (s) |
|---|---|---|---|
| DMSO control 0.06% | 10 | 10/10 (100%) | 282±21 |
| Cinnamophilin 10 μM | 10 | 5/10 (50%)* | 13±5*** |
| 30 μM | 9 | 3/9 (33%)** | 5±2*** |
| Diltiazem 3 μM | 10 | 4/10 (40%)* | 56±30*** |
| SQ29548 1 μM+ozagrel 30 μM | 8 | 8/8 (100%) | 288±42 |
| Glibenclamide 1 μM | 11 | 11/11 (100%) | 258±51 |
| Saline control 0.025 ml ml−1 | 12 | 12/12 (100%) | 268±65 |
| SOD 100 U ml−1+catalase 500 U ml−1 | 10 | 10/10 (100%) | 275±47 |
Abbreviations: DMSO, dimethylsulphoxide; SOD, superoxide dismutase; VF, ventricular fibrillation.
Values of duration of VF are expressed as mean±s.e.mean. Different concentrations of drug stock solutions were used to obtain an equivalent DMSO vehicle concentration of 0.06%.
*P<0.05 and **P<0.01 compared with DMSO vehicle control value by Fisher's exact test; ***P<0.001 compared with DMSO vehicle control group by ANOVA, followed by Dunnett's t-test for multiple comparisons.