Table 1.

Sampling scheme for PK and PD samples

Treatment	Dose (mg kg−1)a	PKb and PDc sample time points (h)
Tesofensine i.v.	0.3	0.75, 1.5, 3
	1	0.75, 1.5, 3
	3	0.75, 1.5, 3
	5	17.5
	10	17.5
M1 i.v.	0.3	0.75, 1.5, 3
	1	0.75, 1.5, 3
	3	0.75, 1.5, 3
	5	17.5
	10	17.5
Tesofensine p.o.	1	0.75, 1.5, 3
	3	0.75, 1.5, 3
	10	0.75, 1.5, 3, 16
	20	16
M1 p.o.	1	0.75, 1.5, 3
	3	0.75, 1.5, 3
	10	0.75, 1.5, 3, 16
	20	16

^aBased on salt form.

^bPK, tesofensine and/or M1 plasma measurements.

^cPD, inhibition of in vivo [³H]WIN35,428 binding.