Skip to main content

View full-text article in PMC

. 2007 Nov 5;153(1):164–174. doi: 10.1038/sj.bjp.0707539

Table 2.

Parameter estimates of final PK model

PK model parameter	Population estimate	Relative s.e.%
K_{a_tesofensine} (h⁻¹)	10 FIX	/
K_{a_M1} (h⁻¹)	5 FIX	/
V_{d_{central tesofensine}} (l kg⁻¹)	17.7	6.1
V_{d_{central M1}} (l kg⁻¹)	13.6	9.1
V_{m_FP} (mg h⁻¹ kg⁻¹)	11.9	19.9
V_{m_MET} (mg h⁻¹ kg⁻¹)	0.823	21.5
V_{m_{EL, tesofensine}} (mg h⁻¹ kg⁻¹)	0.250	39.7
V_{m_{EL, M1}} (mg h⁻¹ kg⁻¹)	0.506	14.4
K_{m_FP} (mg kg⁻¹)	3.59	21.0
K_{m_MET} (mg kg⁻¹)	3.59	21.0
K_{m_{EL, tesofensine}} (mg kg⁻¹)	3.59	21.0
K_{m_{EL, M1}} (mg kg⁻¹)	3.59	21.0
F_tesofensine (%)	87.2	5.1
F_M1 (%)	109	9.3

Variability
Tesofensine (%)	35.7	17.1^a
M1 (%)	36.3	11.4^a

^a

Given on the variance scale.