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. 2001 Jan 22;152(2):301–308. doi: 10.1083/jcb.152.2.301

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© 2001 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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(A and B) Electron microscopy of ventral roots of 6-mo-old P0^+/− op/wt (A) and P0^+/− op/op mice (B). Myelin thickness in P0^+/− op/wt mice is profoundly reduced compared with P0^+/− op/op littermates. Note that in P0^+/− op/wt mice (A) both small (asterisk) and large caliber fibers (double asterisk) are associated with abnormally thin myelin. The presence of fibers with thicker and thinner myelin in one and the same section in A represents segmental demyelination as has been described previously in longitudinal views of teased fibers (Martini et al. 1995). (C) Quantitative analysis of g-ratios of myelinated fibers in ventral roots of P0^+/− op/wt (dark gray bars, n = 3), P0^+/− op/op (bright gray bars, n = 3), and P0^+/+ mice (black bars, n = 3) at the age of six months. Note the reduction in g-ratios in roots from P0^+/− op/op mice reflecting thicker myelin sheaths, when compared with values from P0^+/− op/wt mice. *P < 0.05. P0^+/+ mice display the thickest myelin sheaths. Bars, 5 μm.