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. 1999 Jul 12;146(1):13–28. doi: 10.1083/jcb.146.1.13

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© 1999 The Rockefeller University Press

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

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Expression of reaper in bub1 mutants. Imaginal discs were stained with X-gal to follow expression of a reaper-lacZ reporter construct (rpr-lacZ) in larvae of various genotypes. (A) rpr-lacZ/rpr-lacZ. (B) bub1/bub1 without the rpr reporter gene. (This control was necessitated by the fact that the P elements causing the bub1 mutations contain a lacZ gene.) (C and D) bub1/bub1; rpr-lacZ/rpr-lacZ imaginal discs showing very high levels of β-galactosidase expression, indicating that the cell death program is activated in many cells. Similar results were observed in the brains of these same animals (not shown). Bar, 100 μm.