Table 3.
| Diameter | Area | |
|---|---|---|
| μm | μm2 | |
| Wild-type | ||
| 4 mo | 4.6 ± 2.2 | 20.4 ± 17.6 |
| 1 yr | 6.1 ± 2.1 | 32.8 ± 17.8 |
| 2 yr | 4.1 ± 2.0 | 16.0 ± 14.2 |
| NF-M | ||
| 4 mo | 3.3 ± 1.3 | 9.7 ± 7.6 |
| 1 yr | 3.5 ± 1.3 | 11.0 ± 7.9 |
| 2 yr | 2.9 ± 1.0 | 7.5 ± 5.1 |
| NF-M/H | ||
| 4 mo | 2.8 ± 1.1 | 7.1 ± 5.8 |
| 1 yr | 2.7 ± 1.0 | 6.5 ± 4.8 |
| 2 yr | 2.1 ± 0.8 | 4.1 ± 3.3 |
Axonal diameters were calculated from the axonal areas measured in L5 ventral roots for the indicated ages and genotypes. Values are presented ± SD. Mutants at all ages were statistically different (P < 0.0001) from the relevant age-matched control.