Table 1.
Predicted amino acid sequences representative of the diversity of conotoxins from each sequence group
| Conotoxin | Prepro region Toxin region |
|---|---|
| A1 | VLIIAVLFLTACQLTTAE-TSSRGEQKHRALRSTDKKFKVALLCSPPGSYCFGPAACCSNF-CSTLSDVCQESWSG |
| A2i | .I......................K...........NS.LTRG.T...GA..G.A....QS..DI.AST.NA---- |
| A2ii | ........................K...........NS.LTRG.T...GA..G.A....QS..NI.AST.NA---- |
| A3 | ..........................E.L.......NSRMTKR.T.RHGV..YSYF...KA..NPS.KR.L----- |
| A4 | ........................K...........YSRMTKH.T..EVG.LFAYE...KI..WRPR--.YP.--- |
| A5 | ............................L.......NSRMSKR.T...G..YH.DP...QV..NFPRKH.L----- |
| A6 | .............H..........K...........NSRMTKR.TA..GA.YAAYT....A..NLNTKK.VL.--- |
| A7i | ........................K...........DSRMTKR.T.A.DA.DATTK..IP...NLATKK..VPTFP |
| A7ii | ...........R............K...........NSRMTKR.T.A.DA.DATTE..IL...NLATKK..VPTFP |
| A7iii | .........A..............K...........NSRMTKR.T.A.DA.DATTE..IL...NLATKE..VPTFP |
| A7iv | ........................K...........NSRMTKR.T.A.GA.DATTE..IL...NLATKK..VPTFP |
| A8 | ..............................P.....NSRMTKR.T.G.EA.DATTN..FLT..NLATNK.RSPNFP |
| A9i | .I.F..........IATA.SYA.S.R..PD..LSSRNS.LSKR.LGS.EL.VRDTS...MS..TNNI--.F----- |
| A9ii | .I............IATA.SYA.S.R..PD..LSSRNS.LSKR.LGSREQ.VRDTS...MS..TNNI--.F----- |
| A9iii | .I.I..........IATA.SYA.S.R..PD..LSSRNS.LSKR.LGSREL.VRDTS...MS..TNNI--.F----- |
| L1i | ...........SE.V..DY.RDKWQYRAAS..DAMRN.RDTRT...A.EV.TSKSP..TG.L..HIGGM.HH---- |
| L1ii | .......S...SE.V..DY.RDKWQYRAAS..DAMRN.RDTR-...G.EV.TRHSP..TG.L.NHIGGM.HH---- |
| L2i | ....................YP..Q.R.H.......NS.LTRG.T.RNGF.RYHSH.......H.WAIM.L----- |
| L2ii | ....................YP..Q.R.H.......NS.LTRG.T.RNGA.GYHSH.......H.WAN..L----- |
Single-letter amino acid codes are used. Underlined residues denote presumed proteolytic cleavage sites (22). Names of sequences were used to facilitate discussion of these sequences; proper nomenclature for conotoxins (14) is A1, ABVIA; A2i, ABVIB; A2ii, ABVIC; A3, ABVID; A4, ABVIE; A5, ABVIF; A6, ABVIG; A7i, ABVIH; A7ii, ABVII; A7iii, ABVIJ; A7iv, ABVIK; A8, ABVIL; A9i, ABVIM; A9ii, ABVIN; A9iii, ABVIO; L1i, LVVIA; L1ii, LVVIB; L2i, LVVIC; and L2ii, LVVID.