Table 2.

Dn:Ds ratios, significance levels, and Dn and Ds values among conotoxin sequences

Conotoxin	Conotoxin
	A1	A2i	A2ii	A3	A4	A5	A6	A7i	A7ii	A7iii	A7iv	A8
A1		3.56	4.16	6.65	2.57	3.36	4.34	2.55	2.80	2.77	2.65	5.19
		∗∗∗∗	∗∗∗∗	∗∗∗∗	∗	∗∗∗	∗∗∗∗	∗∗	∗∗∗	∗∗∗	∗∗	∗∗∗∗
A2i	28.16		0.40	4.63	1.63	3.04	2.31	2.12	2.37	2.54	2.01	4.34
	7.91			∗∗∗∗		∗∗∗	∗	∗	∗	∗	∗	∗∗∗∗
A2ii	24.55	1.52		5.80	1.44	3.24	2.63	2.37	2.70	2.90	2.18	5.95
	5.90	3.80		∗∗∗∗		∗∗∗	∗	∗	∗	∗∗	∗	∗∗∗∗
A3	31.84	30.92	26.64		2.52	2.60	1.97	2.17	2.49	2.91	2.14	2.60
	4.79	6.68	4.59		∗	∗		∗	∗	∗∗∗	∗	∗
A4	24.57	21.89	19.27	15.81		1.27	2.23	1.64	1.77	1.84	1.49	2.59
	9.55	13.42	13.37	6.28								∗
A5	27.71	25.14	23.25	18.68	18.77		1.37	2.82	3.52	3.67	3.58	3.67
	8.25	8.27	7.17	7.19	14.81			∗	∗∗	∗∗∗	∗∗	∗∗∗
A6	28.64	23.77	20.78	15.93	14.65	19.05		1.53	1.90	2.08	1.55	2.61
	6.60	10.28	7.91	8.10	6.58	13.91						∗
A7i	30.10	22.60	19.67	24.54	18.07	19.69	14.61		0.79	1.32	1.08	2.68
	11.82	10.66	8.31	11.31	11.04	6.99	9.53
A7ii	27.66	21.30	18.25	23.35	16.87	18.23	14.42	1.87		UND	UND	6.14
	9.89	8.99	6.75	9.39	9.50	5.18	7.60	2.35				∗
A7iii	27.58	23.01	19.79	24.68	17.60	19.02	15.96	3.15	1.23		UND	7.18
	9.97	9.05	6.82	8.47	9.58	5.18	7.66	2.38	0.00		∗	∗∗
A7iv	27.51	20.06	17.12	22.05	15.74	18.30	13.29	2.52	0.61	1.86		3.24
	10.38	9.98	7.87	10.32	10.55	5.11	8.59	2.33	0.00	0.00
A8	31.80	25.05	21.45	21.71	20.41	23.65	15.58	8.38	7.33	8.67	7.70
	6.13	5.74	3.60	8.35	7.89	6.44	5.97	3.12	1.19	1.21	2.38

Above diagonal: Dn/Ds ratios among representative sequences of combined prepro and toxin regions from groups A1 to A8 (see Fig. 1). Significance of pairwise comparisons for the difference between Dn and Ds is indicated below their ratios. ∗, P < 0.005; ∗∗, P < 0.01; ∗∗∗, P < 0.005; ∗∗∗∗, P < 0.001. UND, undefined (Ds = 0). Below diagonal: Dn (above) and Ds (below) values (%). Within-group comparisons are denoted by boxes.