Table 1.
Summary of individual mutation frequency data at three mononucleotide (A)n and three dinucleotide (CA)n loci in Pms2−/−, Mlh1−/−, and DKO mice
| Mice | N | No. Exp. | Exp. freq. | No. Con. | Con. freq. | Total mutation freq. |
|---|---|---|---|---|---|---|
| (A)n | ||||||
| U12235 | ||||||
| Mlh1−/− | 360 | 7 | 0.02 | 67 | 0.19 | 0.21 |
| Pms2−/− | 449 | 9 | 0.02 | 35 | 0.08 | 0.10 |
| DKO | 254 | 8 | 0.03 | 60 | 0.24 | 0.27 |
| WT | 452 | 0 | 0.00 | 1 | 0.002 | 0.002 |
| Aa003063 | ||||||
| Mlh1−/− | 323 | 4 | 0.01 | 78 | 0.24 | 0.25 |
| Pms2−/− | 366 | 6 | 0.02 | 57 | 0.16 | 0.17 |
| DKO | 237 | 4 | 0.02 | 57 | 0.24 | 0.26 |
| L24372 | ||||||
| Mlh1−/− | 345 | 4 | 0.01 | 139 | 0.40 | 0.41 |
| Pms2−/− | 352 | 15 | 0.04 | 83 | 0.24 | 0.28 |
| (CA)n | ||||||
| D1Mit79 | ||||||
| Mlh1−/− | 450 | 44 | 0.10 | 62 | 0.14 | 0.24 |
| Pms2−/− | 350 | 72 | 0.21 | 32 | 0.09 | 0.30 |
| DKO | 299 | 27 | 0.09 | 58 | 0.19 | 0.28 |
| WT | 142 | 0 | 0.00 | 0 | 0.00 | 0.00 |
| D9Mit67 | ||||||
| Mlh1−/− | 234 | 13 | 0.06 | 23 | 0.10 | 0.15 |
| Pms2−/− | 266 | 28 | 0.11 | 10 | 0.04 | 0.14 |
| DKO | 307 | 25 | 0.08 | 24 | 0.08 | 0.16 |
| WT | 103 | 0 | 0.00 | 0 | 0.00 | 0.00 |
| D1Mit355 | ||||||
| Mlh1−/− | 349 | 25 | 0.07 | 54 | 0.15 | 0.23 |
| Pms2−/− | 280 | 45 | 0.16 | 21 | 0.08 | 0.24 |
| WT | 290 | 0 | 0.00 | 3 | 0.01 | 0.01 |
Data on wild-type (WT) control samples at several of the loci are also included. Exp., expansions; Con., contractions.