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. 2008 Jan 30;3(1):e1501. doi: 10.1371/journal.pone.0001501

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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At week 5, mice vaccinated with H5N1 clade 2-dervied vaccines were challenged intranasally with a lethal dose of reassortant influenza virus (A/Viet Nam/1203/2004 (clade 1) or A/Indonesia/05/2005 (clade 2)) and monitored daily for weight loss and mortality. The data are plotted as percentage of the average initial weight. Percentage of (A) original weight or (B) survival following challenge with clade 2 AIndonesia/05/2005 reassortant virus. Percentage of (C) original weight or (D) survival following challenge with clade 1 A/Viet Nam/1203/2004 reassortant virus. Mice that lost greater than 75% body weight were euthanized. Naïve mice were unvaccinated.