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. 2008 Jan 30;3(1):e1501. doi: 10.1371/journal.pone.0001501

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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At week 5, mice vaccinated with clade 2-dervied vaccines were challenged intranasally with a lethal dose of reassortant influenza virus (A/Indonesia/05/2005 (clade 2)) and monitored daily for weight loss and mortality. The data are plotted as percentage of the average initial weight. Percentage of original weight (A) Mice vaccinated with two doses of vaccine (week 0 and 3) and (B) mice vaccinated with a single dose of vaccine (week 0). All mice challenged at week 5. Mice that lost greater than 25% body weight were euthanized.