Table 2.

DNC subjects who had “high risk” early predictors

Early predictors	Subjects, N (%)
Individual predictors
Early dactylitis*	29 (17.3)
Severe anemia†	5 (2.9)
Leukocytosis‡	20 (11.9)
“High risk” combinations§
Early dactylitis and severe anemia	0
Early dactylitis and leukocytosis	3 (2.5)
Severe anemia and leukocytosis	1 (0.5)

^*Dactylitis before 1 year of age.

^†Mean hemoglobin concentration less than or equal to 7 g/dL in second year of life.

^‡Mean leukocyte count of 20 000 /mm³ or greater in second year of life.

^§Combinations associated with a high probability (≥ 0.36) of severe disease by 10 years of age in the CSSCD infant cohort.