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. 1999 Jun 8;96(12):6902–6907. doi: 10.1073/pnas.96.12.6902

Figure 2.

Figure 2

Effect of deletion of both TNFRs on PAI-1 expression in ob/ob mice. Plasma and adipose tissue were collected from 20- to 24-week-old male and female ob/ob mice and ob/ob mice lacking both TNFRs (p55−/−, p75−/−). Plasma PAI-1 antigen (A) or adipose tissue PAI-1 mRNA (B) were analyzed as described in Materials and Methods. (A) n = 6 for each group; bars represent mean ± SD. Comparison of ob/ob vs. ob/ob p55−/−, p75−/−: P < 0.01. (B) Error bars represent the mean for each group. Comparison of ob/ob vs. ob/ob p55−/−, p75−/−: P < 0.0009.