Table 1.

Mice lacking both TNFRs have reduced levels of plasma insulin antigen and adipose tissue TGF-β mRNA

Determination	ob/ob mice	TNFR-deficient ob/ob mice, p55−/−, p75−/−	Lean mice
Insulin antigen	47 ± 12*	20 ± 12	5 ± 1.4
		(P < 0.02)
TGF-β mRNA	3.4 × 105 ± 2 × 105†	0.45 × 105 ± 0.3 × 105	1.5 × 105 ± 0.8 × 105
		(P < 0.01)

n = 6 ± SD. 

^*ng/ml as determined by using a commercially available ELISA assay. 

^†Molecules of TGF-β mRNA/μg total RNA.