Figure 4.

Analysis of LPA in human atherosclerotic plaques and normal arterial tissue. (Upper) Shape change induced by equivalent amounts of LPA extracts of carotid arterial tissue devoid of atherosclerosis (a), the lipid-rich core of a carotid plaque (b), femoral plaque (c), preincubation of platelets with NPTyrPA (10 μM) plus LPA extract of femoral plaque (d), and preincubation of platelets with NPSerPA (5 μM) plus LPA extract of femoral plaque (e). (Lower A) Determination of biologically active LPA in surgical specimens of normal arterial tissue (n = 6; control) and lipid-rich atherosclerotic plaques (n = 10). (Lower B) Determination of biologically active LPA in different regions of carotid atherosclerotic lesions (n = 4). Values are mean ± SEM.