Table 2.
Immunohistochemical detection of p53 protein in primary nonsmall cell lung cancer: Correlation to lymphatic and hematogeneous micrometastasis
| Parameter | No. of patients | p53-positive primary tumors (% of all patients)
|
p53-negative primary tumors (%) | |||
|---|---|---|---|---|---|---|
| Total | 1–30% p53+ cells | 31–60% p53+ cells | 61–100% p53+ cells | |||
| All patients | 47 | 22 (46.8) | 4 (8.5) | 9 (19.1) | 9 (19.1) | 25 (53.2) |
| Lymph node | ||||||
| micrometastasis | ||||||
| BerEp4-positive | 11 | 8 (72.7) | 1 (9.1) | 3 (27.3) | 4 (36.4) | 3 (27.3) |
| BerEp4-negative | 36 | 14 (38.9)* | 3 (8.3) | 6 (16.7) | 5 (13.9) | 22 (61.1) |
| BM micrometastasis | ||||||
| CK18-positive | 18 | 7 (38.9) | 0 (0) | 4 (22.2) | 3 (16.7) | 11 (61.1) |
| CK18-negative | 29 | 15 (51.7) | 4 (13.8) | 5 (17.2) | 6 (20.7) | 14 (48.3) |
*
P < 0.05, total number of patients with p53-positive tumors compared to total number of patients with p53-negative tumors.