Figure 2.

Vaccination with CpG-DNA and L. major lysate is protective. BALB/c mice ears were injected with F/T parasite lysate alone (C) or in combination with CpG-ODN 1826 (A) or control ODN 1911 (B) as described in Materials and Methods and subsequently challenged with infectious organisms. Footpad thickness was assessed weekly. Each line represents the progression of infection in an individual animal. ∗, Euthanized animals. +, A single, protected animal that died because of a cage accident. These data are representative of two independent experiments.