Table 2.

CpG-ODN are ineffective therapy for leishmaniasis in IFN-γ-deficient mice

Treatment group	Survival at 10 weeks
BALB/c-Ifng-tm1Ts (IFN-γ-deficient mice) injected with L. major parasites
1. CpG-ODN 1826	0/20 (0%)
2. CpG-ODN 1911	0/20 (0%)
3. PBS	0/20 (0%)
BALB/c + L. major parasites
1. CpG-ODN 1826	19/20 (95%)
2. CpG-ODN 1911	2/20 (10%)
3. PBS	2/20 (10%)

The footpads of IFN-γ-deficient BALB/c mice and normal BALB/c mice were infected with L. major parasites 4 h before injection with CpG-ODN 1826, control ODN 1911, or PBS as described in Materials and Methods. Animals were euthanized if footpad thickness decreased mobility or if ulceration and necrosis developed.