Abstract
Genetic analysis of the cell cycle of Caulobacter crescentus has identified a DNA synthetic pathway and a cell division pathway (M. A. Osley and A. Newton, J. Mol. Biol. 138:109-128, 1980). The results presented here show that in double-shift experiments the function of the PC2076 gene product, which is required for the initiation of DNA synthesis, depends on completion of a late stage of chromosome replication in the previous cell cycle. These findings suggest a circular organization of steps in the DNA synthetic pathway in C. crescentus.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Degnen S. T., Newton A. Chromosome replication during development in Caulobacter crescentus. J Mol Biol. 1972 Mar 14;64(3):671–680. doi: 10.1016/0022-2836(72)90090-3. [DOI] [PubMed] [Google Scholar]
- Degnen S. T., Newton A. Dependence of cell division on the completion of chromosome replication in Caulobacter. J Bacteriol. 1972 Jun;110(3):852–856. doi: 10.1128/jb.110.3.852-856.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Donachie W. D. Control of cell division in Escherichia coli: experiments with thymine starvation. J Bacteriol. 1969 Oct;100(1):260–268. doi: 10.1128/jb.100.1.260-268.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Donachie W. D. Relationship between cell size and time of initiation of DNA replication. Nature. 1968 Sep 7;219(5158):1077–1079. doi: 10.1038/2191077a0. [DOI] [PubMed] [Google Scholar]
- Helmstetter C. E. DNA synthesis during the division cycle of rapidly growing Escherichia coli B/r. J Mol Biol. 1968 Feb 14;31(3):507–518. doi: 10.1016/0022-2836(68)90424-5. [DOI] [PubMed] [Google Scholar]
- Iba H., Fukuda A., Okada Y. Chromosome replication in Caulobacter crescentus growing in a nutrient broth. J Bacteriol. 1977 Mar;129(3):1192–1197. doi: 10.1128/jb.129.3.1192-1197.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Osley M. A., Newton A. Mutational analysis of developmental control in Caulobacter crescentus. Proc Natl Acad Sci U S A. 1977 Jan;74(1):124–128. doi: 10.1073/pnas.74.1.124. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Osley M. A., Newton A. Regulation of cell cycle events in asymmetrically dividing cells: functions required for DNA initiation and chain elongation in Caulobacter crescentus. J Bacteriol. 1978 Jul;135(1):10–17. doi: 10.1128/jb.135.1.10-17.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Osley M. A., Newton A. Temporal control of the cell cycle in Caulobacter crescentus: roles of DNA chain elongation and completion. J Mol Biol. 1980 Mar 25;138(1):109–128. doi: 10.1016/s0022-2836(80)80007-6. [DOI] [PubMed] [Google Scholar]
- POINDEXTER J. S. BIOLOGICAL PROPERTIES AND CLASSIFICATION OF THE CAULOBACTER GROUP. Bacteriol Rev. 1964 Sep;28:231–295. doi: 10.1128/br.28.3.231-295.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Terrana B., Newton A. Pattern of unequal cell division and development in Caulobacter crescentus. Dev Biol. 1975 Jun;44(2):380–385. doi: 10.1016/0012-1606(75)90409-1. [DOI] [PubMed] [Google Scholar]
- YOSHIKAWA H., O'SULLIVAN A., SUEOKA N. SEQUENTIAL REPLICATION OF THE BACILLUS SUBTILIS CHROMOSOME. 3. REGULATION OF INITIATION. Proc Natl Acad Sci U S A. 1964 Oct;52:973–980. doi: 10.1073/pnas.52.4.973. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Zusman D. R., Krotoski D. M., Cumsky M. Chromosome replication in Myxococcus xanthus. J Bacteriol. 1978 Jan;133(1):122–129. doi: 10.1128/jb.133.1.122-129.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]