Figure 2.

Common architectures of Cre-DNA intermediates in the initial steps of the site-specific recombination pathway as shown schematically in Fig. 1a. Structure i is the Cre/loxS synaptic complex described in this work. Structures ii and iii are described in refs. 11 and 12, respectively. Subunits activated for cleavage of the DNA substrate are colored green and the view is from the catalytic domain side of the synapse.