Figure 1.

Structure of the human 1α-OHase promoter. A 13-kb genomic clone of the human 1α-OHase gene was sequenced, mapped, and analyzed for consensus sequences to known mammalian transcription factors. (A) The nucleotide sequence for the promoter region is given. Underlined sequences correspond to conservative homologous matches to the noted transcription factor or promoter element. The alternating blocked and unblocked sections indicate the truncated promoters AN1–6. (B) A map of the 1α-OHase promoter showing the relative locations of the putative cAMP-inducible transcription factor response elements.