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. Author manuscript; available in PMC: 2008 Jan 16.
Published in final edited form as: Cancer Gene Ther. 2006 Oct 6;14(1):105–116. doi: 10.1038/sj.cgt.7700991

Figure 1.

Figure 1

Schematic diagram of vector construction. These vectors are constructed from an E3 region-deleted Ad5 backbone and do not contain the Ad E1A promoter region (from nucleotide 324 to 488 of the Ad genome). Deletion of the E3 region was necessary, because of the 2.6 kb VEGF promoter we chose was too long to insert into the Ad genome without deletion of adenoviral E3 region. AdCMVE1 and AdVEGFE1 differ in the promoter driving E1A expression. We also used wild-type Ad5 (Ad5wt) as a control.