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. Author manuscript; available in PMC: 2008 Jan 16.
Published in final edited form as: Cancer Gene Ther. 2007 Jan 19;14(4):421–430. doi: 10.1038/sj.cgt.7701028

Figure 2.

Figure 2

Monolayer and spheroid models differ in their assessment of viral infection, replication and oncolysis. (a) Luciferase expression from tumor cells infected with Ad5luc1 show more viral infectivity in monolayer than spheroid assay systems (all error bars represent one standard deviation). (b) Quantitation of viral DNA in tumor cells infected with wild-type Ad shows more viral replication in monolayers than spheroids. (c) An LDH-based cytotoxicity assay of tumor cells infected with wild-type Ad shows more LDH release in monolayers than spheroids (values from uninfected cells have been subtracted from infected cells).