Fig. 2.
Effect of infection of normal mesothelial and ovarian carcinoma cells with Ad.CMV-mda-7 or Ad.PEG-mda-7 on cell viability and apoptosis induction. A: Infection with Ad.CMV-mda-7 or Ad.PEG-mda-7 results in a decrease in cell viability in ovarian cancer cells. Cells were infected with the indicated viruses and cell viability was assessed by MTT assay at 3 d and 6 d post-infection. A significant loss in cell viability was evident in the SKOV3 and OV-4 cell lines. Results are the average from at least three experiments ±SD. B: Infection with Ad.CMV-mda-7 or Ad.PEG-mda-7 variably induces apoptosis in different ovarian cancer cells. The indicated cell type was infected with the designated viruses for 72 h, and Annexin-V binding assay was performed as described in Materials and Methods. Results are the average from at least three experiments ±SD.